.Attributes Medicine, Released online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and epidemiologic studies uncovered that an unique reassortant viral lineage of the Oropouche infection, which has been distributing in the western side Amazon.com region of South america for about a decade, is associated with the recent individual episodes in between 2022 and also 2024.